The Histamine H1 Receptor Participates in the Increased Dorsal Telencephalic Neurogenesis in Embryos from Diabetic Rats.

ABSTRACT: Increased neuron telencephalic differentiation during deep cortical layer formation has been reported in embryos from diabetic mice. Transitory histaminergic neurons within the mesencephalon/rhombencephalon are responsible for fetal histamine synthesis during development, fibers from this system arrives to the frontal and parietal cortex at embryo day (E) 15. Histamine is a neurogenic factor for cortical neural stem cells in vitro through H₁ receptor (H₁R) which is highly expressed during corticogenesis in rats and mice. Furthermore, in utero administration of an H₁R antagonist, chlorpheniramine, decreases the neuron markers microtubuline associated protein 2 (MAP2) and forkhead box protein 2. Interestingly, in the diabetic mouse model of diab

SUBMITTER: Solis KH 

PROVIDER: S-EPMC5735119 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature