Modeling Metabolic Interactions in a Consortium of the Infant Gut Microbiome.

ABSTRACT: The gut microbiome is a complex microbial community that has a significant influence on the host. Microbial interactions in the gut are mediated by dietary substrates, especially complex polysaccharides. In this environment, breakdown products from larger carbohydrates and short chain fatty acids are commonly shared among gut microbes. Understanding the forces that guide microbiome development and composition is important to determine its role in health and in the intervention of the gut microbiome as a therapeutic tool. Recently, modeling approaches such as genome-scale models and time-series analyses have been useful to predict microbial interactions. In this study, a bottom-up approach was followed to develop a mathematical model based on microbial growth equations that incorporate meta

SUBMITTER: Pinto F 

PROVIDER: S-EPMC5735223 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature