Synthesis of Poly-Ubiquitin Chains Using a Bifunctional Ubiquitin Monomer.

ABSTRACT: An optimized large scale and highly reproducible route to orthogonally protected γ-thiolysine is reported. Its utility in the synthesis of bifunctional ubiquitin monomers is demonstrated. These ubiquitin synthons are employed in polymerization reactions giving access to synthetic poly-ubiquitin chains of defined linkage.

SUBMITTER: van der Heden van Noort GJ 

PROVIDER: S-EPMC5735377 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature