Risk of high-grade lesions after atypical glandular cells in cervical screening: a population-based cohort study.

ABSTRACT:

Objectives

To determine how human papillomavirus (HPV) positivity of atypical glandular cells (AGCs) affects the predictive values for the presence of high-grade cervical lesions.

Design

Population-based cohort study.

Setting

Stockholm-Gotland region, Sweden.

Participants

Between 17 February 2014 and 30 June 2016, there were 562 women with AGC detected in a cervical sample. Registry linkages up to 30 June 2016 identified 392 women with an associated HPV test and a histopathological follow-up.

Main outcome measure

Presence of a high-grade cervical lesion in the cervical biopsy taken after the AGC smear, in relation to the HPV status of the AGC-containing index smear.

Results

The proportion of HPV-positive AGC was 56% (n=222). In this group, there w

SUBMITTER: Norman I 

PROVIDER: S-EPMC5735403 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature