Effects of endurance training on skeletal muscle mitochondrial function in Huntington disease patients.

ABSTRACT:

Background

Mitochondrial dysfunction may represent a pathogenic factor in Huntington disease (HD). Physical exercise leads to enhanced mitochondrial function in healthy participants. However, data on effects of physical exercise on HD skeletal muscle remains scarce. We aimed at investigating adaptations of the skeletal muscle mitochondria to endurance training in HD patients.

Methods

Thirteen HD patients and 11 healthy controls completed 26 weeks of endurance training. Before and after the training phase muscle biopsies were obtained from M. vastus lateralis. Mitochondrial respiratory chain complex activities, mitochondrial respiratory capacity, capillarization, and muscle fiber type distribution were determined from muscle samples.

Results

Citrate synthase activity i

SUBMITTER: Mueller SM 

PROVIDER: S-EPMC5735536 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature