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Comparison of Exenatide and Metformin Monotherapy in Overweight/Obese Patients with Newly Diagnosed Type 2 Diabetes.


ABSTRACT: Aims:The present study assessed the therapeutic effect of exenatide and metformin as the initial therapy on overweight/obese patients with newly diagnosed type 2 diabetes (T2D). Methods:The prospective, nonrandomized, interventional study enrolled a total of 230 overweight or obese patients with newly diagnosed T2D who were administrated exenatide or metformin hydrochloride for 12 weeks. Results:224/230 patients, including 106 in the exenatide group and 118 in the metformin group, completed the 12-week treatment. Both exenatide and metformin significantly decreased the HbA1c levels in overweight/obese patients with newly diagnosed T2D (all P < 0.05). The reduction in HbA1c and the proportion of patients with HbA1c?

SUBMITTER: Liu J 

PROVIDER: S-EPMC5735665 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature

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Comparison of Exenatide and Metformin Monotherapy in Overweight/Obese Patients with Newly Diagnosed Type 2 Diabetes.

Liu Jia J   Hu Yanjin Y   Xu Yuan Y   Jia Yumei Y   Miao Li L   Wang Guang G  

International journal of endocrinology 20171120


<h4>Aims</h4>The present study assessed the therapeutic effect of exenatide and metformin as the initial therapy on overweight/obese patients with newly diagnosed type 2 diabetes (T2D).<h4>Methods</h4>The prospective, nonrandomized, interventional study enrolled a total of 230 overweight or obese patients with newly diagnosed T2D who were administrated exenatide or metformin hydrochloride for 12 weeks.<h4>Results</h4>224/230 patients, including 106 in the exenatide group and 118 in the metformin  ...[more]

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