Leishmania braziliensis SCD6 and RBP42 proteins, two factors with RNA binding capacity.

ABSTRACT:

Background

The study of RNA binding proteins (RBPs) is of great relevance for understanding processes like post-transcriptional control of gene expression. The post-transcriptional mechanisms are particularly important in Leishmania parasites and related trypanosomatids since transcriptional regulation is almost absent in them. Thus, RBPs should be essential during the development of these parasites and for survival strategies against the adverse conditions that they face during their life-cycle. This work was aimed to do a structural and biochemical characterization of two Leishmania braziliensis proteins, which were previously found in pull-down assays using an HSP70 RNA as bait. At that time, these proteins were annotated as hypothetical proteins (LbrM.25.2210 and LbrM.30.3080)

SUBMITTER: Nocua PA 

PROVIDER: S-EPMC5735676 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature