Predictive model identifies strategies to enhance TSP1-mediated apoptosis signaling.

ABSTRACT: BACKGROUND:Thrombospondin-1 (TSP1) is a matricellular protein that functions to inhibit angiogenesis. An important pathway that contributes to this inhibitory effect is triggered by TSP1 binding to the CD36 receptor, inducing endothelial cell apoptosis. However, therapies that mimic this function have not demonstrated clear clinical efficacy. This study explores strategies to enhance TSP1-induced apoptosis in endothelial cells. In particular, we focus on establishing a computational model to describe the signaling pathway, and using this model to investigate the effects of several approaches to perturb the TSP1-CD36 signaling network. METHODS:We constructed a molecularly-detailed mathematical model of TSP1-mediated intracellular signaling via the CD36 receptor based on literature evidence.

SUBMITTER: Wu Q 

PROVIDER: S-EPMC5735807 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature