Similar genomic proportions of copy number variation within gray wolves and modern dog breeds inferred from whole genome sequencing.

ABSTRACT:

Background

Whole genome re-sequencing data from dogs and wolves are now commonly used to study how natural and artificial selection have shaped the patterns of genetic diversity. Single nucleotide polymorphisms, microsatellites and variants in mitochondrial DNA have been interrogated for links to specific phenotypes or signals of domestication. However, copy number variation (CNV), despite its increasingly recognized importance as a contributor to phenotypic diversity, has not been extensively explored in canids.

Results

Here, we develop a new accurate probabilistic framework to create fine-scale genomic maps of segmental duplications (SDs), compare patterns of CNV across groups and investigate their role in the evolution of the domestic dog by using information from 34 cani

SUBMITTER: Serres-Armero A 

PROVIDER: S-EPMC5735816 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature