Optimizing Treatment of Complicated Grief: A Randomized Clinical Trial.

ABSTRACT:

Importance

To our knowledge, this is the first placebo-controlled randomized clinical trial to evaluate the efficacy of antidepressant pharmacotherapy, with and without complicated grief psychotherapy, in the treatment of complicated grief.

Objective

To confirm the efficacy of a targeted complicated grief treatment (CGT), determine whether citalopram (CIT) enhances CGT outcome, and examine CIT efficacy without CGT.

Design, setting, and participants

Included in the study were 395 bereaved adults who met criteria for CG recruited from March 2010 to September 2014 from academic medical centers in Boston, Massachusetts; New York, New York; Pittsburgh, Pennsylvania; and San Diego, California. Co-occurring substance abuse, psychosis, mania, and cognitive impairment were exc

SUBMITTER: Shear MK 

PROVIDER: S-EPMC5735848 | biostudies-literature | 2016 Jul

REPOSITORIES: biostudies-literature