Chemotherapy diminishes lipid storage capacity of adipose tissue in a preclinical model of colon cancer.

ABSTRACT:

Background

Accelerated loss of adipose tissue in cancer is associated with shorter survival, and reduced quality of life. Evidence is emerging suggesting tumour association with alterations in adipose tissue, but much less is known about drug-related mechanisms contributing to adipose atrophy. Identification of mechanisms by which tumour and cancer treatments, such as chemotherapy, affect adipose tissue are required to develop appropriate therapeutic interventions to prevent fat depletion in cancer. This pre-clinical study aimed to assess alterations in adipose tissue during the clinical course of cancer.

Methods

Fischer 344 rats bearing the Ward colorectal tumour were euthanized before chemotherapy, after 1- cycle, or 2-cycles of a combination chemotherapy consisting of Iri

SUBMITTER: Ebadi M 

PROVIDER: S-EPMC5735884 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature