Transdermal delivery of gentamicin using dissolving microneedle arrays for potential treatment of neonatal sepsis.

ABSTRACT: Neonatal infections are a leading cause of childhood mortality in low-resource settings. World Health Organization guidelines for outpatient treatment of possible serious bacterial infection (PSBI) in neonates and young infants when referral for hospital treatment is not feasible include intramuscular gentamicin (GEN) and oral amoxicillin. GEN is supplied as an aqueous solution of gentamicin sulphate in vials or ampoules and requires health care workers to be trained in dose calculation or selection of an appropriate dose based on the patient's weight band and to have access to safe injection supplies and appropriate sharps disposal. A simplified formulation, packaging, and delivery method to treat PSBI in low-resource settings could decrease user error and expand access to lifesaving outp

SUBMITTER: Gonzalez-Vazquez P 

PROVIDER: S-EPMC5736097 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature