Metabolic Profiling of Adiponectin Levels in Adults: Mendelian Randomization Analysis.

ABSTRACT:

Background

Adiponectin, a circulating adipocyte-derived protein, has insulin-sensitizing, anti-inflammatory, antiatherogenic, and cardiomyocyte-protective properties in animal models. However, the systemic effects of adiponectin in humans are unknown. Our aims were to define the metabolic profile associated with higher blood adiponectin concentration and investigate whether variation in adiponectin concentration affects the systemic metabolic profile.

Methods and results

We applied multivariable regression in ≤5909 adults and Mendelian randomization (using cis-acting genetic variants in the vicinity of the adiponectin gene as instrumental variables) for analyzing the causal effect of adiponectin in the metabolic profile of ≤37 545 adults. Participants were largely Eur

SUBMITTER: Borges MC 

PROVIDER: S-EPMC5736126 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature