The influence of spatial resolution and smoothing on the detectability of resting-state and task fMRI.

ABSTRACT: Functional MRI blood oxygen level-dependent (BOLD) signal changes can be subtle, motivating the use of imaging parameters and processing strategies that maximize the temporal signal-to-noise ratio (tSNR) and thus the detection power of neuronal activity-induced fluctuations. Previous studies have shown that acquiring data at higher spatial resolutions results in greater percent BOLD signal changes, and furthermore that spatially smoothing higher resolution fMRI data improves tSNR beyond that of data originally acquired at a lower resolution. However, higher resolution images come at the cost of increased acquisition time, and the number of image volumes also influences detectability. The goal of our study is to determine how the detection power of neuronally induced BOLD fluctuations acqui

SUBMITTER: Molloy EK 

PROVIDER: S-EPMC5736131 | biostudies-literature | 2014 Feb

REPOSITORIES: biostudies-literature