Therapeutic potential of mesenchymal stromal cells for hypoxic ischemic encephalopathy: A systematic review and meta-analysis of preclinical studies.

ABSTRACT:

Introduction

Neonatal hypoxic ischemic encephalopathy (HIE) is a devastating neurologic condition with high mortality rates and long-term complications for surviving infants. Mesenchymal stem/stromal cells (MSCs) have emerged as novel therapeutic agents with promising results in experimental studies of HIE. The purpose of this study is to (a) methodically review the current preclinical literature describing MSC therapy in animal models of HIE, (b) quantify the effect size in regards to functional neurologic outcome, and (c) identify research gaps/limitations that should be addressed prior to future preclinical and clinical studies.

Methods

Adhering to the Systematic Review Protocol for Animal Intervention Studies, a systematic search of English articles was performed. Eligib

SUBMITTER: Archambault J 

PROVIDER: S-EPMC5736208 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature