Endotheliopathy is associated with higher levels of cell-free DNA following major trauma: A prospective observational study.

ABSTRACT:

Background

Cell free deoxyribonucleic acid (cfDNA) has been proposed as a biomarker of secondary complications following trauma. Raised thrombomodulin and syndecan-1 levels have been used to indicate endotheliopathy, and are associated with inflammation, coagulopathy, and mortality. The current study aimed to analyse the association between cfDNA and biomarkers of endotheliopathy in a cohort of trauma patients, and whether raised levels of cfDNA were associated with poorer clinical outcomes.

Methods

Serum thrombomodulin and syndecan-1 were used as biomarkers of endotheliopathy and compared to plasma cfDNA in trauma patients from two prospective longitudinal observational studies. Cohort A (n = 105) had a predicted injury severity score (ISS) >8, and had blood sampled within

SUBMITTER: Naumann DN 

PROVIDER: S-EPMC5736230 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature