Human Adenosine A_2A Receptor: Molecular Mechanism of Ligand Binding and Activation.

ABSTRACT: Adenosine receptors (ARs) comprise the P1 class of purinergic receptors and belong to the largest family of integral membrane proteins in the human genome, the G protein-coupled receptors (GPCRs). ARs are classified into four subtypes, A₁, A_2A, A_2B, and A₃, which are all activated by extracellular adenosine, and play central roles in a broad range of physiological processes, including sleep regulation, angiogenesis and modulation of the immune system. ARs are potential therapeutic targets in a variety of pathophysiological conditions, including sleep disorders, cancer, and dementia, which has made them important targets for structural biology. Over a decade of research and innovation has culminated with the publication of more than 30 crystal str

SUBMITTER: Carpenter B 

PROVIDER: S-EPMC5736361 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature