Superoxide Production by NADPH Oxidase Intensifies Macrophage Antiviral Responses during Diabetogenic Coxsackievirus Infection.

ABSTRACT: Coxsackievirus B infections are suspected environmental triggers of type 1 diabetes (T1D) and macrophage antiviral responses may provide a link to virus-induced T1D. We previously demonstrated an important role for NADPH oxidase (NOX)-derived superoxide production during T1D pathogenesis, as NOX-deficient NOD mice (NOD.Ncf1^m1J ) were protected against T1D due, in part, to impaired proinflammatory TLR signaling in NOD.Ncf1^m1J macrophages. Therefore, we hypothesized that loss of NOX-derived superoxide would dampen diabetogenic antiviral macrophage responses and protect from virus-induced diabetes. Upon infection with a suspected diabetogenic virus, Coxsackievirus B3 (CB3), NOD.Ncf1^m1J mice remained resistant to virus-induced autoimmune di

SUBMITTER: Burg AR 

PROVIDER: S-EPMC5736405 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature