STAT5B: A Differential Regulator of the Life and Death of CD4⁺ Effector Memory T Cells.

ABSTRACT: Understanding the control of Ag restimulation-induced T cell death (RICD), especially in cancer immunotherapy, where highly proliferating T cells will encounter potentially large amounts of tumor Ags, is important now more than ever. It has been known that growth cytokines make T cells susceptible to RICD, but the precise molecular mediators that govern this in T cell subsets is unknown until now. STAT proteins are a family of transcription factors that regulate gene expression programs underlying key immunological processes. In particular, STAT5 is known to favor the generation and survival of memory T cells. In this study, we report an unexpected role for STAT5 signaling in the death of effector memory T (TEM) cells in mice and humans. TEM cell death was prevented with neutralizing anti-

SUBMITTER: Majri SS 

PROVIDER: S-EPMC5736408 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature