Modulation of the Alternative Pathway of Complement by Murine Factor H-Related Proteins.

ABSTRACT: Factor H (FH) is a key alternative pathway regulator that controls complement activation both in the fluid phase and on specific cell surfaces, thus allowing the innate immune response to discriminate between self and foreign pathogens. However, the interrelationships between FH and a group of closely related molecules, designated the FH-related (FHR) proteins, are currently not well understood. Whereas some studies have suggested that human FHR proteins possess complement regulatory abilities, recent studies have shown that FHR proteins are potent deregulators. Furthermore, the roles of the FHR proteins have not been explored in any in vivo models of inflammatory disease. In this study, we report the cloning and expression of recombinant mouse FH and three FHR proteins (FHR proteins A-C).

SUBMITTER: Antonioli AH 

PROVIDER: S-EPMC5736413 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature