Changes in gene expression in small bowel neuroendocrine tumors associated with progression to metastases.

ABSTRACT:

Background

Small bowel neuroendocrine tumors (SBNETs) present frequently with metastases, yet little is known about the molecular basis of this progression. This study sought to identify the serial differential expression of genes between normal small bowel, primary small bowel neuroendocrine tumors, and liver metastases.

Methods

RNA isolated from matched normal small bowel tissue, primary small bowel neuroendocrine tumors, and liver metastases in 12 patients was analyzed with whole transcriptome expression microarrays and RNA-Seq. Changes in gene expression between primary small bowel neuroendocrine tumors and normal small bowels, and liver metastases versus primary small bowel neuroendocrine tumors were calculated. Common genes that were differentially expressed serially (

SUBMITTER: Keck KJ 

PROVIDER: S-EPMC5736454 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature