Identifying barriers to accrual in radiation oncology randomized trials.

ABSTRACT:

Background

Data about factors driving accrual to radiation oncology trials are limited. In oncology, 30%-40% of trials are considered unsuccessful, many because of poor accrual. The goal of the present study was to inform the design of future trials by evaluating the effects of institutional, clinician, and patient factors on accrual rates to a randomized radiation oncology trial.

Methods

Investigators participating in sabr-comet (NCT01446744), a randomized phase ii trial open in Canada, Europe, and Australia that is evaluating the role of stereotactic ablative radiotherapy (sabr) in oligometastatic disease, were invited to complete a survey about factors affecting accrual. Institutional ethics approval was obtained. The primary endpoint was the annual accrual rate per insti

SUBMITTER: Laba JM 

PROVIDER: S-EPMC5736492 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature