Oral Microbiota: Microbial Biomarkers of Metabolic Syndrome Independent of Host Genetic Factors.

ABSTRACT: The oral microbiota plays a critical role in both local and systemic inflammation. Metabolic syndrome (MetS) is characterized by low-grade inflammation, and many studies have been conducted on the gut microbiota from stool specimens. However, the etiological role of the oral microbiota in the development of MetS is unclear. In this study, we analyzed the oral and gut microbiome from 228 subgingival plaque and fecal samples from a Korean twin-family cohort with and without MetS. Significant differences in microbial diversity and composition were observed in both anatomical niches. However, a host genetic effect on the oral microbiota was not observed. A co-occurrence network analysis showed distinct microbiota clusters that were dependent on the MetS status. A comprehensive analysis of the

SUBMITTER: Si J 

PROVIDER: S-EPMC5736563 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature