The Fast Spiking Subpopulation of Striatal Neurons Coding for Temporal Cognition of Movements.

ABSTRACT: Background: Timing dysfunctions occur in a number of neurological and psychiatric disorders such as Parkinson's disease, obsessive-compulsive disorder, autism and attention-deficit-hyperactivity disorder. Several lines of evidence show that disrupted timing processing is involved in specific fronto-striatal abnormalities. The striatum encodes reinforcement learning and procedural motion, and consequently is required to represent temporal information precisely, which then guides actions in proper sequence. Previous studies highlighted the temporal scaling property of timing-relevant striatal neurons; however, it is still unknown how this is accomplished over short temporal latencies, such as the sub-seconds to seconds range. Methods: We designed a task with a series of timing behaviors that

SUBMITTER: Shen B 

PROVIDER: S-EPMC5736568 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature