Clearance of a persistent picornavirus infection is associated with enhanced pro-apoptotic and cellular immune responses.

ABSTRACT: Long-term persistent viral infections cause substantial morbidity and associated economic losses in human and veterinary contexts. Yet, the mechanisms associated with establishment of persistent infections are poorly elucidated. We investigated immunomodulatory mechanisms associated with clearance versus persistence of foot-and-mouth disease virus (FMDV) in micro-dissected compartments of the bovine nasopharynx by microarray. The use of laser-capture microdissection allowed elucidation of differential gene regulation within distinct anatomic compartments critical to FMDV infection. Analysis of samples from transitional and persistent phases of infection demonstrated significant differences in transcriptome profiles of animals that cleared infection versus those that became persistently inf

SUBMITTER: Stenfeldt C 

PROVIDER: S-EPMC5736604 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature