JAK/STAT and TGF-ß activation as potential adverse outcome pathway of TiO₂NPs phototoxicity in Caenorhabditis elegans.

ABSTRACT: Titanium dioxide nanoparticles (TiO₂NPs) are widely used nanoparticles, whose catalytic activity is mainly due to photoactivation. In this study, the toxicity of TiO₂NPs was investigated on the nematode Caenorhabditis elegans, with and without UV activation. Comparative analyses across the four treatments revealed that UV-activated TiO₂NPs led to significant reproductive toxicity through oxidative stress. To understand the underlying molecular mechanism, transcriptomics and metabolomics analyses were conducted, followed by whole-genome network-based pathway analyses. Differential expression analysis from microarray data revealed only 4 DEGs by exposure to TiO₂NPs alone, compared to 3,625 and 3,286 DEGs by UV alone and UV-activated TiO₂

SUBMITTER: Kim H 

PROVIDER: S-EPMC5736661 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature