Identification of new genes associated to senescent and tumorigenic phenotypes in mesenchymal stem cells.

ABSTRACT: Although human mesenchymal stem cells (hMSCs) are a powerful tool for cell therapy, prolonged culture times result in replicative senescence or acquisition of tumorigenic features. To identify a molecular signature for senescence, we compared the transcriptome of senescent and young hMSCs with normal karyotype (hMSCs/n) and with a constitutional inversion of chromosome 3 (hMSC/inv). Senescent and young cells from both lineages showed differentially expressed genes (DEGs), with higher levels in senescent hMSCs/inv. Among the 30 DEGs in senescent hMSC/inv, 11 are new candidates for biomarkers of cellular senescence. The functional categories most represented in senescent hMSCs were related to cellular development, cell growth/proliferation, cell death, cell signaling/interaction, and cell mo

SUBMITTER: Medeiros Tavares Marques JC 

PROVIDER: S-EPMC5736717 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature