Medication adherence in patients with apparent resistant hypertension: findings from the SYMPATHY trial.

ABSTRACT:

Aims

Hypertension is only controlled in approximately 35% of the patients, which could be partially due to nonadherence. Recently, bioanalytical assessment of adherence to blood pressure (BP) lowering drugs has gaining interest. Our aim was to explore possible determinants of nonadherence in treatment resistant hypertension, assessed by objective screening for antihypertensive agents in serum. The secondary aim was to study the effect of adherence on the change in BP.

Methods

This project was a substudy of SYMPATHY; an open-label randomized-controlled trial to assess the effect of renal denervation on BP 6 months after treatment compared to usual care in patients with resistant hypertension. Stored serum samples were screened for antihypertensive agents to assess adherence a

SUBMITTER: de Jager RL 

PROVIDER: S-EPMC5736834 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature