External evaluation of population pharmacokinetic models for ciclosporin in adult renal transplant recipients.

ABSTRACT:

Aims

Several population pharmacokinetic (popPK) models for ciclosporin (CsA) in adult renal transplant recipients have been constructed to optimize the therapeutic regimen of CsA. However, little is known about their predictabilities when extrapolated to different clinical centres. Therefore, this study aimed to externally evaluate the predictive ability of CsA popPK models and determine the potential influencing factors.

Methods

A literature search was conducted and the predictive performance was determined for each selected model using an independent data set of 62 patients (471 predose and 500 2-h postdose concentrations) from our hospital. Prediction-based diagnostics and simulation-based normalized prediction distribution error were used to evaluate model predictability

SUBMITTER: Mao JJ 

PROVIDER: S-EPMC5736841 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature