Impact of non-adherence on the safety and efficacy of uric acid-lowering therapies in the treatment of gout.

ABSTRACT:

Aims

Dual-urate-lowering therapy (ULT) with xanthine oxidase inhibitor and uricosuric medications is a treatment option for severe gout. Uricosuric agents can cause hyperuricosuria, a risk factor for nephrolithiasis and acute uric acid nephropathy. The aims of the present study were to simulate the relationship between suboptimal drug adherence and efficacy, and to quantify the risk of hyperuricosuria in gout patients receiving mono- and dual-ULTs.

Methods

The impact of poor medication adherence was studied using two-compartment pharmacokinetic (PK) models based on published evidence, and a semi-mechanistic four-compartment pharmacodynamic (PD) model. The PKPD model was used to simulate mono and dual-ULT in gout patients with either under-excretion (lowered clearance) or ove

SUBMITTER: Hill-McManus D 

PROVIDER: S-EPMC5736842 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature