A Specialized Peptidoglycan Synthase Promotes Salmonella Cell Division inside Host Cells.

ABSTRACT: Bacterial cell division has been studied extensively under laboratory conditions. Despite being a key event in the bacterial cell cycle, cell division has not been explored in vivo in bacterial pathogens interacting with their hosts. We discovered in Salmonella enterica serovar Typhimurium a gene absent in nonpathogenic bacteria and encoding a peptidoglycan synthase with 63% identity to penicillin-binding protein 3 (PBP3). PBP3 is an essential cell division-specific peptidoglycan synthase that builds the septum required to separate daughter cells. Since S Typhimurium carries genes that encode a PBP3 paralog-which we named PBP3_SAL-and PBP3, we hypothesized that there are different cell division events in host and nonhost environments. To test this, we generat

SUBMITTER: Castanheira S 

PROVIDER: S-EPMC5736910 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature