Incremental effects of antihypertensive drugs: instrumental variable analysis.

ABSTRACT:

Objectives

To assess the incremental effects of adding extra antihypertensive drugs from a new class to a patient's regimen.

Design

Instrumental variable analysis of data from SPRINT (Systolic Blood Pressure Intervention Trial). To account for confounding by indication-when treatments seem less effective if they are administered to sicker patients-randomization status was used as the instrumental variable. Patients' randomization status was either intensive (systolic blood pressure target <120 mm Hg) or standard (systolic blood pressure target <140 mm Hg) treatment. Results from instrumental variable models were compared with those from standard multivariable models.

Setting

Secondary data analysis of a randomized clinical trial conducted at 102 sites in 2010-15.

P

SUBMITTER: Markovitz AA 

PROVIDER: S-EPMC5736968 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature