Preferential Initiation and Spread of Anoxic Depolarization in Layer 4 of Rat Barrel Cortex.

ABSTRACT: Anoxic depolarization (AD) is a hallmark of ischemic brain damage. AD is associated with a spreading wave of neuronal depolarization and an increase in light transmittance. However, initiation and spread of AD across the layers of the somatosensory cortex, which is one of the most frequently affected brain regions in ischemic stroke, remains largely unknown. Here, we explored the initiation and propagation of AD in slices of the rat barrel cortex using extracellular local field potential (LFP) recordings and optical intrinsic signal (OIS) recordings. We found that ischemia-like conditions induced by oxygen-glucose deprivation (OGD) evoked AD, which manifested as a large negative LFP shift and an increase in light transmittance. AD typically initiated in one or more barrels and further spre

SUBMITTER: Juzekaeva E 

PROVIDER: S-EPMC5736969 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature