Intrinsic protein disorder reduces small-scale gene duplicability.

ABSTRACT: Whereas the rate of gene duplication is relatively high, only certain duplications survive the filter of natural selection and can contribute to genome evolution. However, the reasons why certain genes can be retained after duplication whereas others cannot remain largely unknown. Many proteins contain intrinsically disordered regions (IDRs), whose structures fluctuate between alternative conformational states. Due to their high flexibility, IDRs often enable protein-protein interactions and are the target of post-translational modifications. Intrinsically disordered proteins (IDPs) have characteristics that might either stimulate or hamper the retention of their encoding genes after duplication. On the one hand, IDRs may enable functional diversification, thus promoting duplicate retentio

SUBMITTER: Banerjee S 

PROVIDER: S-EPMC5737077 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature