Abnormal Brain Activation During Theory of Mind Tasks in Schizophrenia: A Meta-Analysis.

ABSTRACT: Social cognition abilities are severely impaired in schizophrenia (SZ). The current meta-analysis used foci of 21 individual studies on functional abnormalities in the schizophrenic brain in order to identify regions that reveal convergent under- or over-activation during theory of mind (TOM) tasks. Studies were included in the analyses when contrasting tasks that require the processing of mental states with tasks which did not. Only studies that investigated patients with an ICD or DSM diagnosis were included. Quantitative voxel-based meta-analyses were done using Seed-based d Mapping software. Common TOM regions like medial-prefrontal cortex and temporo-parietal junction revealed abnormal activation in schizophrenic patients: Under-activation was identified in the medial prefrontal corte

SUBMITTER: Kronbichler L 

PROVIDER: S-EPMC5737081 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature