Hematological Effects of Gold Nanorods on Erythrocytes: Hemolysis and Hemoglobin Conformational and Functional Changes.

ABSTRACT: Gold nanorods (GNRs) are a unique class of metal nanostructures that have attractive potentials in biomedical applications, and the concern on their biological safety is concomitantly increasing. Hemocompatibility is extremely important as their contact with blood circulation is unavoidable during in vivo delivery. Herein, two kinds of GNRs coated with hexadecyltrimethylammonium bromide (C-GNRs) or poly(sodium-p-styrenesulfonate) are used to test their potential toxicological effects in blood. C-GNRs with positive surface charges efficiently induce hemolysis when encountering erythrocytes. Cellular internalization of C-GNRs is found, and they subsequently bind with hemoglobin, forming bioconjugates. The interaction between hemoglobin and C-GNR (stoichiometry 32.7:1) is regulated by

SUBMITTER: Zhao X 

PROVIDER: S-EPMC5737108 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature