Therapy and outcomes of primary central nervous system lymphoma in the United States: analysis of the National Cancer Database.

ABSTRACT: Although the role of radiation therapy and chemotherapy in primary central nervous system lymphoma (PCNSL) has evolved considerably over the past decade, the application of treatment modalities in the community has not been evaluated. We analyzed the use of chemotherapy, radiation therapy, and associated overall survival, among 9165 HIV-negative PCSNL cases reported to the US National Cancer Database in 2004-2013. During this time, the proportion of patients receiving chemotherapy significantly increased from 65.6% to 78.8% (P for trend <.0001), whereas the proportion receiving radiation therapy decreased from 37.6% to 18.8% (P < .0001). Adjusting for the varying distribution of clinical and sociodemographic characteristics by type of treating facility, the risk of not receiv

SUBMITTER: Fallah J 

PROVIDER: S-EPMC5737162 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature