The clinical value of patient-derived glioblastoma tumorspheres in predicting treatment response.

ABSTRACT:

Background

Advances from glioma stemlike cell (GSC) research, though increasing our knowledge of glioblastoma (GBM) biology, do not influence clinical decisions yet. We explored the translational power of GSC-enriched cultures from patient-derived tumorspheres (TS) in predicting treatment response.

Methods

The relationship between TS growth and clinical outcome was investigated in 52 GBMs treated with surgical resection followed by radiotherapy and temozolomide (TMZ). The effect on TS of radiation (6 to 60 Gy) and of TMZ (3.9 μM to 1 mM) was related with patients' survival.

Results

Generation of TS was an independent factor for poor overall survival (OS) and poor progression-free survival (PFS) (P < .0001 and P = .0010, respectively). Growth rate and clonogenicity of

SUBMITTER: D'Alessandris QG 

PROVIDER: S-EPMC5737323 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature