Cell-to-cell variability and robustness in S-phase duration from genome replication kinetics.

ABSTRACT: Genome replication, a key process for a cell, relies on stochastic initiation by replication origins, causing a variability of replication timing from cell to cell. While stochastic models of eukaryotic replication are widely available, the link between the key parameters and overall replication timing has not been addressed systematically. We use a combined analytical and computational approach to calculate how positions and strength of many origins lead to a given cell-to-cell variability of total duration of the replication of a large region, a chromosome or the entire genome. Specifically, the total replication timing can be framed as an extreme-value problem, since it is due to the last region that replicates in each cell. Our calculations identify two regimes based on the spread betw

SUBMITTER: Zhang Q 

PROVIDER: S-EPMC5737480 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature