Prioritizing tests of epistasis through hierarchical representation of genomic redundancies.

ABSTRACT: Epistasis is defined as a statistical interaction between two or more genomic loci in terms of their association with a phenotype of interest. Epistatic loci that are identified using data from Genome-Wide Association Studies (GWAS) provide insights into the interplay among multiple genetic factors, with applications including assessment of susceptibility to complex diseases, decision making in precision medicine, and gaining insights into disease mechanisms. Since the number of genomic loci assayed by GWAS is extremely large (usually in the order of millions), identification of epistatic loci is a statistically difficult and computationally intensive problem. Even when only pairwise interactions are considered, the size of the search space ranges from hundreds of millions to billions of l

SUBMITTER: Cowman T 

PROVIDER: S-EPMC5737499 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature