CompAnnotate: a comparative approach to annotate base-pairing interactions in RNA 3D structures.

ABSTRACT: The analysis of RNA tertiary structure is hindered by the fact that not too many structural data are available and a significant amount of them are in low resolution. Due to the atomic coordinate errors posed by the limitations of low-resolution RNA three-dimensional structures, it becomes a critical challenge to extract key geometric characteristics of RNA, particularly, the interaction of bases. To address this issue, we have devised a comparative method, named CompAnnotate, that utilizes more precise structural information of high-resolution homologs to annotate the base-pairing interactions in the low-resolution structures, by aligning and making comparative geometric assessments. The benchmarking results show that our method can improve the annotations of the existing methods signific

SUBMITTER: Islam S 

PROVIDER: S-EPMC5737500 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature