Convergence and Divergence of Brain Network Dysfunction in Deficit and Non-deficit Schizophrenia.

ABSTRACT: Deficit schizophrenia (DS), characterized by primary and enduring negative symptoms, has been considered as a pathophysiologically distinct schizophrenic subgroup. Neuroimaging characteristics of DS, especially functional brain network architecture, remain largely unknown. Resting-state functional magnetic resonance imaging and graph theory approaches were employed to investigate the topological organization of whole-brain functional networks of 114 male participants including 33 DS, 41 non-deficit schizophrenia (NDS) and 40 healthy controls (HCs). At the whole-brain level, both the NDS and DS group exhibited lower local efficiency (Eloc) than the HC group, implying the reduction of local specialization of brain information processing (reduced functional segregation). The DS, but not NDS g

SUBMITTER: Yu M 

PROVIDER: S-EPMC5737538 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature