Osteonecrosis in children and adolescents with acute lymphoblastic leukemia: a therapeutic challenge.

ABSTRACT: Osteonecrosis (ON) represents one of the most common and debilitating sequelae of antileukemic treatment in children and adolescents with acute lymphoblastic leukemia (ALL). Systematic screening strategies can focus on early detection and intervention to prevent ON from progressing to stages associated with pain and functional impairment. These strategies hold promise for reducing ON-associated morbidity without the risk of impairing leukemia control. Herein, we critically reviewed clinical data on pharmacological, nonpharmacological/nonsurgical, and surgical (including cellular) treatment options for ON, which are covered in the literature and/or are conceivable based on the supposed underlying ON pathophysiology. Prevention of ON progression is of paramount importance, and attempts seem

SUBMITTER: Kuhlen M 

PROVIDER: S-EPMC5737600 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature