Restriction endonuclease triggered bacterial apoptosis as a mechanism for long time survival.

ABSTRACT: Programmed cell death (PCD) under certain conditions is one of the features of bacterial altruism. Given the bacterial diversity and varied life style, different PCD mechanisms must be operational that remain largely unexplored. We describe restriction endonuclease (REase) mediated cell death by an apoptotic pathway, beneficial for isogenic bacterial communities. Cell death is pronounced in stationary phase and when the enzyme exhibits promiscuous DNA cleavage activity. We have elucidated the molecular mechanism of REase mediated cell killing and demonstrate that released nutrients from dying cells support the growth of the remaining cells in the population. These findings illustrate a new intracellular moonlighting role for REases which are otherwise established host defence arsenals. REa

SUBMITTER: Nagamalleswari E 

PROVIDER: S-EPMC5737642 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature