Dissociation of Brain Activation in Autism and Schizotypal Personality Disorder During Social Judgments.

ABSTRACT:

Background

There are overlaps between autism and schizophrenia but these are particularly pronounced, especially in social domains, for higher functioning individuals with autism spectrum disorders (ASD) or schizotypal personality disorder (SPD). It is not known whether these overlapping social deficits result from shared or distinct brain mechanisms. We therefore compared social cognition in ASD and SPD using functional magnetic resonance imaging (fMRI).

Methods

Twenty-one individuals with SPD, 28 with ASD and 33 controls were compared with respect to clinical symptoms using the Positive and Negative Syndrome Scale; social cognition, using a social judgment task and Ekman 60 faces task; and brain activation using an fMRI task of social judgment.

Results

The ASD and S

SUBMITTER: Stanfield AC 

PROVIDER: S-EPMC5737648 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature