A Systematic and Meta-analytic Review of Neural Correlates of Functional Outcome in Schizophrenia.

ABSTRACT: Individuals with schizophrenia are burdened with impairments in functional outcome, despite existing interventions. The lack of understanding of the neurobiological correlates supporting adaptive function in the disorder is a significant barrier to developing more effective treatments. This research conducted a systematic and meta-analytic review of all peer-reviewed studies examining brain-functional outcome relationships in schizophrenia. A total of 53 (37 structural and 16 functional) brain imaging studies examining the neural correlates of functional outcome across 1631 individuals with schizophrenia were identified from literature searches in relevant databases occurring between January, 1968 and December, 2016. Study characteristics and results representing brain-functional outcome r

SUBMITTER: Wojtalik JA 

PROVIDER: S-EPMC5737663 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature