Family-specific scaling laws in bacterial genomes.

ABSTRACT: Among several quantitative invariants found in evolutionary genomics, one of the most striking is the scaling of the overall abundance of proteins, or protein domains, sharing a specific functional annotation across genomes of given size. The size of these functional categories change, on average, as power-laws in the total number of protein-coding genes. Here, we show that such regularities are not restricted to the overall behavior of high-level functional categories, but also exist systematically at the level of single evolutionary families of protein domains. Specifically, the number of proteins within each family follows family-specific scaling laws with genome size. Functionally similar sets of families tend to follow similar scaling laws, but this is not always the case. To understa

SUBMITTER: De Lazzari E 

PROVIDER: S-EPMC5737699 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature