Extreme Deviations from Expected Evolutionary Rates in Archaeal Protein Families.

ABSTRACT: Origin of new biological functions is a complex phenomenon ranging from single-nucleotide substitutions to the gain of new genes via horizontal gene transfer or duplication. Neofunctionalization and subfunctionalization of proteins is often attributed to the emergence of paralogs that are subject to relaxed purifying selection or positive selection and thus evolve at accelerated rates. Such phenomena potentially could be detected as anomalies in the phylogenies of the respective gene families. We developed a computational pipeline to search for such anomalies in 1,834 orthologous clusters of archaeal genes, focusing on lineage-specific subfamilies that significantly deviate from the expected rate of evolution. Multiple potential cases of neofunctionalization and subfunctionalization were i

SUBMITTER: Petitjean C 

PROVIDER: S-EPMC5737733 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature