Role of radiotherapy fractionation in head and neck cancers (MARCH): an updated meta-analysis.

ABSTRACT:

Background

The Meta-Analysis of Radiotherapy in squamous cell Carcinomas of Head and neck (MARCH) showed that altered fractionation radiotherapy is associated with improved overall and progression-free survival compared with conventional radiotherapy, with hyperfractionated radiotherapy showing the greatest benefit. This update aims to confirm and explain the superiority of hyperfractionated radiotherapy over other altered fractionation radiotherapy regimens and to assess the benefit of altered fractionation within the context of concomitant chemotherapy with the inclusion of new trials.

Methods

For this updated meta-analysis, we searched bibliography databases, trials registries, and meeting proceedings for published or unpublished randomised trials done between Jan 1, 2009

SUBMITTER: Lacas B 

PROVIDER: S-EPMC5737765 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature