The role of epigenomics in personalized medicine.

ABSTRACT:

Introduction

Epigenetics is the study of reversible modifications to chromatin and their extensive and profound effects on gene regulation. To date, the role of epigenetics in personalized medicine has been under-explored. Therefore, this review aims to highlight the vast potential that epigenetics holds.

Areas covered

We first review the cell-specific nature of epigenetic states and how these can vary with developmental stage and in response to environmental factors. We then summarize epigenetic biomarkers of disease, with a focus on diagnostic tests, followed by a detailed description of current and pipeline drugs with epigenetic modes of action. Finally, we discuss epigenetic biomarkers of drug response.

Expert commentary

Epigenetic variation can yield information

SUBMITTER: Kronfol MM 

PROVIDER: S-EPMC5737812 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature